In short: All Rejuran products use the same core ingredient, polynucleotides (PN) purified from salmon DNA, which support skin repair and collagen production. The difference is where and why each is used. Rejuran Healer is the standard full-face formula for overall skin quality. Rejuran i is made for the thin skin around the eyes. Rejuran S targets wrinkles and depressed scars. Rejuran HB plus adds lidocaine for comfort. The right choice depends on your main concern and the area, as assessed in consultation.
Key takeaways
- Rejuran is made by PharmaResearch in South Korea. All its formulas are based on salmon-derived polynucleotides.
- Rejuran Healer suits overall texture, fine lines, elasticity and dull or stressed skin across the face.
- Rejuran i is designed for delicate under-eye and eye-area skin, such as crepey texture and fine lines.
- Rejuran S is aimed at deeper imperfections, especially depressed (atrophic) acne scars.
- Results build gradually over a course, often three sessions a few weeks apart, and they improve skin quality rather than adding volume.
What Rejuran is, and what it isn’t
Rejuran is a skin booster. It is injected in tiny amounts into the dermis to improve skin quality, not to lift or fill. Its active ingredient is polynucleotide (PN), purified DNA fragments from salmon. PharmaResearch describes Rejuran products as medical devices for the temporary improvement of facial wrinkles, and notes that repeated treatments (three to four sessions) increase effectiveness and duration.
PN vs PDRN. You may also see PDRN (polydeoxyribonucleotide), often called “salmon DNA”. Both come from DNA, but PN has longer chains and a thicker, gel-like structure that gives more structural support, while PDRN has shorter fragments and works mainly through cell signalling. Roxana offers both Rejuran and a separate salmon DNA (PDRN) therapy.
The Rejuran formulas compared
| Formula | Designed for | Typical concerns | Notes |
|---|---|---|---|
| Rejuran Healer | Full face, neck and other skin areas | Dullness, uneven texture, fine lines, loss of elasticity, enlarged-looking pores, skin stressed by sun or procedures | The original, all-round formula |
| Rejuran i | Eye area | Crepey under-eye skin, fine lines, crow’s feet, thin skin | Formulated for thin, delicate skin |
| Rejuran S | Targeted scars and deeper imperfections | Atrophic (depressed) acne scars, wrinkles | Used focally rather than across the whole face |
| Rejuran HB plus | Full face | Similar to Healer, plus hydration | Contains lidocaine to reduce discomfort, and hyaluronic acid |
Which one for your concern?
| Your main concern | Often considered | Why |
|---|---|---|
| Overall dull, tired or uneven skin | Rejuran Healer (or HB plus) | All-round improvement in skin quality |
| Crepey under-eyes or fine lines around the eyes | Rejuran i | Made for thin eye-area skin |
| Dark circles caused by thin skin | Rejuran i, possibly with other treatments | Thicker skin can make vessels less visible; pigment-related dark circles need a different approach |
| Hollow tear troughs (volume loss) | Not Rejuran alone; filler or other options | Rejuran improves skin quality, not volume |
| Depressed acne scars | Rejuran S, often alongside resurfacing or subcision | Supports repair in scar areas |
| Sensitive to injection discomfort | Rejuran HB plus | Contains lidocaine |
| Skin recovering after laser or sun | Rejuran Healer | Supports skin repair |
What to expect
- Course: Roxana’s Rejuran page lists typically three sessions, three to four weeks apart, with each session taking around 30–40 minutes.
- During: numbing cream, then many small, shallow injections. Small bumps are expected.
- After: bumps usually settle within 24–48 hours. Avoid make-up for 24 hours and postpone intense workouts and heat for a couple of days, as Roxana’s page advises.
- Results: improvement often begins within two to three weeks and continues over the course.
- Not suitable: during pregnancy or breastfeeding, with active skin infection, or with a fish or salmon allergy (tell your clinician about any allergies).
In Dubai’s heat, plan sessions so you can avoid strong sun, saunas and outdoor exercise for a couple of days afterwards.
How Rejuran fits with other treatments
- With Botox: Botox relaxes movement lines, and Rejuran improves skin quality.
- With filler: filler restores volume, and Rejuran improves the skin over it.
- With lasers or RF microneedling: often combined for scars and texture, with spacing between treatments.
- Versus Profhilo or other skin boosters: see Rejuran vs Profhilo.
How Roxana Aesthetics can help
At Roxana Aesthetics Clinic on Al Wasl Road, Rejuran treatment starts with an assessment of skin quality, under-eye skin and any scarring, so the right formula and area can be chosen. The clinic treats the face, under-eyes, neck, acne scar areas and décolletage, and can combine Rejuran with resurfacing or other skin boosters where appropriate.
The bottom line
Rejuran Healer, Rejuran i and Rejuran S share the same polynucleotide technology but are matched to different jobs. Healer suits overall skin quality, it suits the delicate eye area, and S suits scars and deeper imperfections. HB plus adds comfort. Results build gradually over a course. To find out which suits your skin, book a consultation with Roxana Aesthetics.
Frequently asked questions
What is the difference between Rejuran Healer and Rejuran i?
Both use salmon-derived polynucleotides. Rejuran Healer is the standard formula for overall skin quality across the face, while Rejuran i is designed for the thin, delicate skin around the eyes, such as crepey under-eye skin and fine lines. Your clinician chooses based on the area being treated.
Is Rejuran S good for acne scars?
Rejuran S is aimed at deeper imperfections such as depressed acne scars. Small studies suggest polynucleotides can help improve atrophic scars, often best combined with resurfacing such as fractional laser or RF microneedling. Results are gradual, and several sessions are usually needed.
Does Rejuran i get rid of dark circles?
Rejuran i can improve thin, crepey under-eye skin, which may make dark circles caused by visible vessels look less obvious. It won’t fix dark circles caused by pigmentation or hollow tear troughs. These may need pigment treatment or filler instead. An assessment identifies the cause.
Is Rejuran PDRN or PN?
The manufacturer describes Rejuran as polynucleotide (PN), purified from salmon DNA. PDRN (polydeoxyribonucleotide) is related but made of shorter fragments and behaves differently. Both are used in skin rejuvenation and are sometimes both called “salmon DNA”.
How many Rejuran sessions do I need?
A typical course is about three sessions, spaced three to four weeks apart, according to Roxana’s Rejuran page. The manufacturer notes that repeated treatments improve effectiveness and duration. Maintenance sessions may be suggested afterwards.
Is Rejuran painful?
Rejuran involves many small injections, so it can be uncomfortable. Numbing cream is used, and Rejuran HB plus contains lidocaine to reduce discomfort. Small bumps are normal and usually settle within a day or two.
Can I have Rejuran if I’m allergic to fish?
Tell your clinician about any fish or salmon allergy before treatment. Rejuran is derived from salmon DNA, so your clinician will assess whether it is appropriate for you.
How much does Rejuran cost in Dubai?
Cost depends on the formula, the areas treated and the number of sessions in your plan. A personalised quote follows a consultation.
This article is general medical information, not a substitute for individual assessment. Product availability and formulations may vary. Skin boosters are medical treatments that should be given by a qualified practitioner.
Medically Reviewed by: Dr. Natallia Kaliashuk
