In short: RRS HA Long Lasting and Profhilo are both hyaluronic acid skin boosters for dehydrated, dull or crepey skin, but they work differently. Profhilo uses a high concentration of thermally stabilised hyaluronic acid (no chemical cross-linker), injected at a few points, typically in two sessions. RRS HA Long Lasting uses a lightly cross-linked hyaluronic acid with an amino-acid buffer, spread through the skin over a course of sessions. Both improve hydration and skin quality rather than adding volume. The better choice depends on your skin, the area and your preferred treatment plan.
Key takeaways
- Both are injectable hyaluronic acid products for skin quality, not fillers for volume or lifting.
- Profhilo combines high and low molecular-weight hyaluronic acid in “hybrid cooperative complexes”, stabilised by heat rather than a chemical cross-linker.
- RRS HA Long Lasting contains BDDE cross-linked hyaluronic acid plus a buffer of amino acids.
- Profhilo is commonly given in two sessions four weeks apart. Roxana’s RRS course is commonly three sessions.
- Many people’s choice comes down to skin thickness, the area, comfort with the injection technique, and how many visits suit them.
What skin boosters do
Skin boosters place small amounts of hydrating material in the skin to improve hydration, elasticity, texture and glow. They don’t change your face shape. In Dubai, sun exposure, air-conditioning and long working hours can leave skin dehydrated even in humid weather, and skin boosters are a popular way to improve skin quality without a filled look.
How the two products differ
| Profhilo | RRS HA Long Lasting | |
|---|---|---|
| Manufacturer | IBSA (Switzerland/Italy) | Skin Tech Pharma Group (Spain) |
| Hyaluronic acid | High and low molecular-weight HA in hybrid cooperative complexes, stabilised by heat with no chemical cross-linker | BDDE cross-linked HA with an amino-acid buffer (manufacturer) |
| HA concentration | High (64 mg in 2 ml) | Lower (21 mg in 3 ml, per the manufacturer) |
| Technique | Typically five “Bio Aesthetic Points” (BAP) per side of the face; the product spreads through the skin | Micro-injections distributed across the area |
| Typical course | Two sessions, four weeks apart (Roxana’s Profhilo page) | A course of three sessions is commonly recommended (Roxana’s RRS page) |
| Main aims | Hydration, laxity of skin quality, glow | Hydration, photoageing, thin or atrophic skin |
| Regulatory | Medical device | Class III medical device (EU) |
Profhilo’s composition and safety record are summarised in a review of almost ten years of post-marketing data (Salti et al., 2025). Roxana’s RRS HA Lifting treatment also uses RRS Hyalift 75, a separate RRS formula, depending on the skin.
Which suits dehydrated skin?
| Your skin or goal | Often considered | Why |
|---|---|---|
| Dehydrated, dull skin with early laxity | Profhilo | High HA concentration; good for overall bounce and glow with few injection points |
| Dehydrated, sun-damaged or thin, crepey skin | RRS HA Long Lasting | Aimed at photoageing and dermal atrophy, with an amino-acid buffer |
| Neck, décolletage or hands | Either, depending on skin | Both are used beyond the face |
| Prefer fewer visits | Profhilo | Usually two sessions |
| Prefer a gradual, staged course | RRS | Usually three sessions |
| Sensitive to many injection points | Profhilo (BAP) | Fewer injection points |
| Need volume or contour | Neither; consider filler or collagen stimulators | Skin boosters don’t add structure |
What to expect
- Consultation: skin assessment, medical history, and whether a skin booster suits your goals.
- During: numbing may be used. Profhilo usually involves a few small injections per side. RRS involves more, smaller injections.
- Afterwards: small bumps at injection points usually settle within hours to a day. Mild redness or bruising is possible. Avoid make-up for a day, and skip saunas and intense exercise briefly.
- Results: hydration often improves within days, and skin quality continues to improve over the following weeks.
- Maintenance: many people have a top-up a few times a year, depending on skin and lifestyle.
- Not suitable: during pregnancy or breastfeeding, with active skin infection, or with a known allergy to hyaluronic acid products.
Profhilo or RRS vs other skin boosters
- Rejuran (polynucleotide): focuses on skin repair and is often chosen for under-eyes and scars (see Rejuran Healer vs Rejuran i vs Rejuran S).
- Salmon DNA (PDRN): regeneration-focused.
- Collagen stimulators such as Sculptra: build collagen and gradual volume over months.
Combining products in a planned sequence is common. Your clinician will space treatments appropriately.
Dubai tips
- Book a few weeks before events, because hydration and glow build over time.
- Avoid strong sun and heat for a day or two after injections.
- Keep up daily sunscreen and moisturiser to protect results.
How Roxana Aesthetics can help
At Roxana Aesthetics Clinic on Al Wasl Road, both Profhilo and RRS HA treatments are available after a skin assessment. The clinic also offers Rejuran, salmon DNA (PDRN) therapy and other skin boosters, so the plan can match your skin rather than a single product.
The bottom line
Both RRS HA Long Lasting and Profhilo can improve hydration and skin quality without adding volume. Profhilo offers a high-concentration formula in fewer sessions. RRS HA Long Lasting offers a cross-linked formula with an amino-acid buffer over a staged course. The best choice depends on your skin, the area and your schedule. Book a consultation with Roxana Aesthetics for a personalised recommendation.
Frequently asked questions
What is the difference between Profhilo and RRS HA Long Lasting?
Profhilo contains a high concentration of high and low molecular-weight hyaluronic acid stabilised by heat, without a chemical cross-linker, and is usually injected at a few points in two sessions. RRS HA Long Lasting contains BDDE cross-linked hyaluronic acid with an amino-acid buffer and is spread through the skin over a course of sessions. Both improve hydration and skin quality.
Which is better for dehydrated skin?
Both can help dehydrated skin. Profhilo is often chosen for dull skin with early laxity, and RRS HA Long Lasting for thin, sun-damaged or crepey skin. The best choice depends on your skin’s thickness, the area and how many sessions suit you, as assessed in consultation.
How many Profhilo sessions do I need?
Roxana’s Profhilo page notes that two sessions, four weeks apart, are usually recommended. Maintenance sessions are often suggested every few months, depending on your skin and lifestyle.
How many RRS sessions do I need?
Roxana’s RRS HA Lifting page notes that a course of three sessions is commonly recommended. Your clinician will adjust the plan based on how your skin responds.
Will skin boosters make my face look puffy?
No. Skin boosters are designed to improve skin quality and hydration, not to add volume or change face shape. Small bumps at injection points are normal and usually settle within hours to a day.
Can I combine Profhilo with Botox or filler?
Yes. Skin boosters are often combined with Botox for movement lines and filler for volume. Your clinician will plan the order and timing so each treatment can settle properly.
Is Profhilo or RRS safe?
Both are hyaluronic acid-based medical devices with established use. Common side effects are temporary bumps, redness and bruising. They aren’t suitable during pregnancy or breastfeeding, over an active skin infection, or with an allergy to hyaluronic acid products.
How much do Profhilo and RRS cost in Dubai?
Cost depends on the product, the area and the number of sessions. A personalised plan and quote follow a consultation.
This article is general medical information, not a substitute for individual assessment. Product formulations and indications may vary by market. Skin boosters must be given by a qualified medical practitioner.
